Sengenics can help, with solutions to support discovery of biomarker signatures. Our high-density protein microarray assays enable highly specific and reproducible detection of disease-relevant autoantibodies directly from patient serum.
Candidate Autoantibody Biomarkers for Anti-drug Antibodies in RA Patients
Candidate autoantibody biomarkers for the prediction of anti-drug antibody (ADAb) development in adalimumab treated rheumatoid arthritis patients. Heat map of autoantibody presence and hierarchical clustering for the presence or absence of anti-drug antibody and clinical response. Plasma samples were taken at baseline and post 24 weeks of adalimumab therapy. Autoantibody levels were measured in RFU and are represented on a color scale.
Source: Chen, P., et. al., Anti-TROVE2 Antibody Determined by Immune-Related Array May Serve as a Predictive Marker for Adalimumab Immunogenicity and Effectiveness in RA, Journal of Immunology Research (2021).
