Companion Diagnostics for Cancer and Autoimmune Drugs

Sengenics has an extensive track record of working with academic and pharmaceutical collaborators to discover novel autoantibody signatures for autoimmune disease and cancer immunotherapy drugs. These signatures usually consist of a relatively low number of biomarkers that have high sensitivity and specificity, making the results highly amenable to be converted into a low-cost companion diagnostic.

Key benefits and uses

  • identify patients who are most likely to benefit from a particular drug;
  • identify patients who are more likely to be at increased risk for developing serious ADRs;
  • monitor response to drugs in order to adjust dosage or treatment regimes to achieve improved safety and/or efficacy.
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High-throughput autoantibody profiling against 1600+ proteins

Quantification of autoantibodies to 200+ clinically relevant CT antigens

Simultaneous screening of 100+
wild-type and mutant p53

Multi-antigen, multi-domain
COVID-19 antibody test

Sengenics - Functional Proteomics | Krex Technology | Protein Microarray Supplier

Sengenics is a Functional Proteomics company that leverages its patented KREX technology to discover autoantibody biomarker signatures for prediction of drug response and severe immune-related adverse events (irAEs). KREX can also be used to identify autoantibody biomarkers to diagnose cancer, autoimmune, neurodegenerative or infectious diseases with higher sensitivity and specificity than conventional diagnostic tests. Some autoantibodies that are identified as diagnostic biomarkers may be protective and have potential in themselves as therapeutic biomolecules.

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