Using conventional methods, it would be necessary to screen every single human protein, splice variant, neoantigen or microbial antigen to discover the total repertoire of autoantigens within a disease.
By using the Orvar™ Autoantigen Discovery Technology, the identity of all the autoantigens and antigens that make up the Autoproteome™ can be discovered. The Autoproteome™ is defined as the totality of all possible autoantigens and neoantigens representing a given disease and its sub-types.
Orvar™ identifies all possible autoantigens and antigens within a human at a given time which are associated with a disease.
Once the Autoproteome™ is identified, we then use our patented KREX™ technology to clone, express and attach every single autoantigen or antigen on to a Sengenics protein array. This customised protein array then serves as a validated, true positive antigen and autoantigen library which is disease-specific. Applications for this protein array include the discovery of autoantibodies for characterisation of diseases either as biomarkers for early diagnostics, protective autoantibodies or intra-disease stratification.