KREX Publications

Publication : Autoimmune DiseasesLinks

Anti-TROVE2 Antibody Determined by Immune-Related Array May Serve as a Predictive Marker for Adalimumab Immunogenicity and Effectiveness in RA

Chen, Po-Ku, Joung-Liang Lan, Yi-Ming Chen, et al. 2021. “Anti-TROVE2 Antibody Determined by Immune-Related Array May Serve as a Predictive Marker for Adalimumab Immunogenicity and Effectiveness in RA.” Edited by Baohui Xu. Journal of Immunology Research 2021 (March): 1–13. doi:10.1155/2021/6656121

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Detection of Putative Autoantibodies in Systemic Lupus Erythematous using a Novel Native-Conformation Protein Microarray Platform

Mak, Anselm, Nien Yee Kow, Nur Hafiza Ismail, et al. 2020. “Detection of Putative Autoantibodies in Systemic Lupus Erythematous Using a Novel Native-Conformation Protein Microarray Platform.” Lupus 29 (14): 1948–54. doi:10.1177/0961203320959696
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Identification of Novel Native Autoantigens in Rheumatoid Arthritis

Poulsen, Thomas B. G., Dres Damgaard, Malene Møller Jørgensen, et al. 2020. “Identification of Novel Native Autoantigens in Rheumatoid Arthritis.” Biomedicines 8 (6): 141. doi:10.3390/biomedicines8060141
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Autoantibodies Targeting TLR and SMAD Pathways Define New Subgroups in Systemic Lupus Erythematosus

Lewis, Myles J., Michael B. McAndrew, Colin Wheeler, et al. 2018. “Autoantibodies Targeting TLR and SMAD Pathways Define New Subgroups in Systemic Lupus Erythematosus.” Journal of Autoimmunity 91 (July): 1–12. doi:10.1016/j.jaut.2018.02.009
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Publications : CancerLinks

B cells and Antibody Production in Melanoma

Da Gama Duarte, Jessica, Janique M. Peyper, and Jonathan M. Blackburn. 2018. “B Cells and Antibody Production in Melanoma.” Mammalian Genome 29 (11): 790–805. doi:10.1007/s00335-018-9778-z

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A Diagnostic Autoantibody Signature for Primary Cutaneous Melanoma

Zaenker, Pauline, Johnny Lo, Robert Pearce, et al. 2018. “A Diagnostic Autoantibody Signature for Primary Cutaneous Melanoma.” Oncotarget 9 (55): 30539–51. doi:10.18632/oncotarget.25669.

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Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin followed by Ipilimumab in Patients with Advanced Metastatic Melanoma

Da Gama Duarte, Jessica, Sagun Parakh, Miles C. Andrews, et al. 2018. “Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin Followed by Ipilimumab in Patients with Advanced Metastatic Melanoma.” Frontiers in Immunology 9. doi:10.3389/fimmu.2018.00411.

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Novel Potential Serological Prostate Cancer Biomarkers Using CT100+ Cancer Antigen Microarray Platform in a Multi-Cultural South African Cohort

Adeola, Henry A., Muneerah Smith, Lisa Kaestner, et al. 2016. “Novel Potential Serological Prostate Cancer Biomarkers Using CT100+ Cancer Antigen Microarray Platform in a Multi-Cultural South African Cohort.” Oncotarget 7 (12): 13945–64. doi:10.18632/oncotarget.7359.

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Development Of A Novel, Quantitative Protein Microarray Platform for the Multiplexed Serological Analysis of Autoantibodies to Cancer-Testis Antigens

Beeton-Kempen, Natasha, Jessica Duarte, Aubrey Shoko, et al. 2014. “Development of a Novel, Quantitative Protein Microarray Platform for the Multiplexed Serological Analysis of Autoantibodies to Cancer-Testis Antigens.” International Journal of Cancer 135 (8): 1842–51. doi:10.1002/ijc.28832.

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Serologic Autoantibodies as Diagnostic Cancer Biomarkers — A Review

Zaenker, Pauline, and Melanie R. Ziman. 2013. “Serologic Autoantibodies as Diagnostic Cancer Biomarkers—A Review.” Cancer Epidemiology and Prevention Biomarkers 22 (12): 2161–81. doi:10.1158/1055-9965.EPI-13-0621.

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Protein Function Microarrays: Design, Use and Bioinformatic Analysis in Cancer Biomarker Discovery and Quantitation

Duarte, Jessica, Jean-Michel Serufuri, Nicola Mulder, et al. 2013. “Protein Function Microarrays: Design, Use and Bioinformatic Analysis in Cancer Biomarker Discovery and Quantitation.” In Bioinformatics of Human Proteomics, edited by Xiangdong Wang, 39–74. Translational Bioinformatics. Dordrecht: Springer Netherlands. doi:10.1007/978-94-007-5811-7_3

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Seromic Analysis of Antibody Responses in Non-Small Cell Lung Cancer Patients and Healthy Donors Using Conformational Protein Arrays

Gnjatic, Sacha, Colin Wheeler, Martin Ebner, et al. 2009. “Seromic Analysis of Antibody Responses in Non-Small Cell Lung Cancer Patients and Healthy Donors Using Conformational Protein Arrays.” Journal of Immunological Methods 341 (1–2): 50–58. doi:10.1016/j.jim.2008.10.016

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Functional Protein Microarrays for Parallel Characterisation of P53 Mutants

Boutell, Jonathan M., Darren J. Hart, Benjamin L. J. Godber, et al. 2004. “Functional Protein Microarrays for Parallel Characterisation of P53 Mutants.” PROTEOMICS 4 (7): 1950–58. doi:https://doi.org/10.1002/pmic.200300722

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Publications : Neurodegenerative DiseasesLinks

Augmentation of Autoantibodies by Helicobacter pylori in Parkinson’s Disease Patients May Be Linked to Greater Severity

Suwarnalata, Gunasekaran, Ai Huey Tan, Hidayah Isa, et al. 2016. “Augmentation of Autoantibodies by Helicobacter Pylori in Parkinson’s Disease Patients May Be Linked to Greater Severity.” PloS One 11 (4): e0153725. doi:10.1371/journal.pone.0153725

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Publications : Infectious DiseasesLinks
Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort

Smith, M.; Abdesselem, H.B.; Mullins, M.; Tan, T.-M.; Nel, A.J.M.; Al-Nesf, M.A.Y.; Bensmail, I.; Majbour, N.K.; Vaikath, N.N.; Naik, A.; et al. Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort. Viruses 2021, 13, 786. https://doi.org/10.3390/ v13050786
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Quantitative, Epitope-specific, Serological Screening of COVID-19 Patients Using a Novel Multiplexed Array-based Immunoassay Platform

Blackburn, Jonathan M, Nurdiana Anuar, Ti Myen Tan, et al. 2020. “Quantitative, Epitope-Specific, Serological Screening of COVID-19 Patients Using a Novel Multiplexed Array-Based Immunoassay Platform.” Preprint. Infectious Diseases (except HIV/AIDS). doi:10.1101/2020.09.25.20201269

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COVID-19 Antibody Testing: From Hype to Immunological Reality

Gray, C. M., J. Peter, M. Mendelson, et al. 2020. “COVID-19 Antibody Testing: From Hype to Immunological Reality.” South African Medical Journal 110 (9): 837–41

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Identifying Protein Biomarkers in Predicting Disease Severity of Dengue Virus Infection Using Immune-Related Protein Microarray

Soe, Hui, Yean Yong, Mazen M. Al-Obaidi, et al. 2018. “Identifying Protein Biomarkers in Predicting Disease Severity of Dengue Virus Infection Using Immune-Related Protein Microarray.” Medicine 97 (5). doi:10.1097/MD.0000000000009713

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Autoantibody Profile of Patients Infected with Knowlesi Malaria

Liew, Jonathan, Amirah Amir, Yeng Chen, et al. 2015. “Autoantibody Profile of Patients Infected with Knowlesi Malaria.” Clinica Chimica Acta; International Journal of Clinical Chemistry 448 (August): 33–38. doi:10.1016/j.cca.2015.06.006

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Publications : Other DiseasesLinks

Potential Novel Proteomic Biomarkers for Diagnosis of Vertebral Osteomyelitis Identified using an Immunomics Protein Array Technique

Chen, Chang-Hua, Ing-Lin Chang, Shu-Hui Wang, et al. 2020. “Potential Novel Proteomic Biomarkers for Diagnosis of Vertebral Osteomyelitis Identified Using an Immunomics Protein Array Technique: Two Cases Reports.” Medicine 99 (43): e22852. doi:10.1097/MD.0000000000022852

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A Novel Method to Identify Autoantibodies against Putative Target Proteins in Serum from beta-Thalassemia Major: A Pilot Study

Sumera, Afshan, Nur Diana Anuar, Ammu Kutty Radhakrishnan, et al. 2020. “A Novel Method to Identify Autoantibodies against Putative Target Proteins in Serum from Beta-Thalassemia Major: A Pilot Study.” Biomedicines 8 (5): 97. doi:10.3390/biomedicines8050097

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Publications : TechnologyLinks

Applications of Functional Protein Arrays for Detection and Development of Autoantibody-based Diagnostics and Therapeutics

Aziz, Farhanah, Muneera Smith, and Jonathan M Blackburn. 2019. “Autoantibody-Based Diagnostic Biomarkers: Technological Approaches to Discovery and Validation.” In Autoantibodies and Cytokines, edited by Wahid Ali Khan. IntechOpen. doi:10.5772/intechopen.75200

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Autoantibody-Based Diagnostic Biomarkers: Technological Approaches to Discovery and Validation

Aziz, Farhanah et al. 2018. “Applications of Functional Protein Arrays for Detection and Development of Autoantibody-based Diagnostics and Therapeutics.” International Biopharmaceutical Industry 1 (2). https://www.biopharmaceuticalmedia.com/applications-of-functional-protein-arrays-for-detection-and-development-of-autoantibody-based-diagnostic-and-therapeutic/

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Advances in the Development of Human Protein Microarrays

Duarte, Jessica G., and Jonathan M. Blackburn. 2017. “Advances in the Development of Human Protein Microarrays.” Expert Review of Proteomics 14 (7): 627–41. doi:10.1080/14789450.2017.1347042

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Protein Function Microarrays for Customised Systems-Oriented Proteome Analysis

Blackburn, Jonathan M., and Aubrey Shoko. 2011. “Protein Function Microarrays for Customised Systems-Oriented Proteome Analysis.” Methods in Molecular Biology (Clifton, N.J.) 785: 305–30. doi:10.1007/978-1-61779-286-1_21

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Seromic analysis of antibody responses in non-small cell lung cancer patients and healthy donors using conformational protein arrays


Sacha Gnjatic, Colin Wheeler, Martin Ebner, Erika Ritter, Anne Murray, Nasser K.Altorki, Cathy A.Ferrara, Henry Hepburne-Scott, Sarah Joyce, Jens Koopman, Michael B.McAndrew, Nicholas Workman, Gerd Ritter, Rachel Fallon, Lloyd J.Old. 2009. “Seromic analysis of antibody responses in non-small cell lung cancer patients and healthy donors using conformational protein arrays.” Journal of Immunological Methods (Volume 341, Issues 1–228 February 2009, Pages 50-58)

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Sengenics is a Functional Proteomics company that leverages its patented KREX technology to discover autoantibody biomarker signatures for prediction of drug response and severe immune-related adverse events (irAEs). KREX can also be used to identify autoantibody biomarkers to diagnose cancer, autoimmune, neurodegenerative or infectious diseases with higher sensitivity and specificity than conventional diagnostic tests. Some autoantibodies that are identified as diagnostic biomarkers may be protective and have potential in themselves as therapeutic biomolecules.

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