Patented technology for the production of full-length, correctly folded and functional proteins
Identify all autoantigens and antigens that make up the Autoproteome*
(*) Totality of all possible autoantigens and neoantigens representing a given disease and its sub-types
Quantify autoantibodies using a pin-prick of blood
Autoantigen discovery database
Bespoke content and project design services
| Publication : Autoimmune Diseases | Links |
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Autoantibodies Targeting TLR and SMAD Pathways Define New Subgroups in Systemic Lupus Erythematosus Lewis, Myles J. et al. 2018. “Autoantibodies Targeting TLR and SMAD Pathways Define New Subgroups in Systemic Lupus Erythematosus.” Journal of Autoimmunity 91: 1–12. https://linkinghub.elsevier.com/retrieve/pii/S0896841118300234 | View Paper |
Identification of Novel Native Autoantigens in Rheumatoid Arthritis Poulsen, Thomas B. G. et al. 2020 “Identification of Novel Native Autoantigens in Rheumatoid Arthritis.” Biomedicines 2020, 8(6), 141. https://www.mdpi.com/2227-9059/8/6/141/htm | View Paper |
Detection of Putative Autoantibodies in Systemic Lupus Erythematous using a Novel Native-Conformation Protein Microarray Platform Mak, A., Kow, N. Y., Ismail, N. H., Anuar, N. D., Rutt, N. H., & Cho, J. (2020). Detection of putative autoantibodies in systemic lupus erythematous using a novel native-conformation protein microarray platform. 1–7. https://doi.org/10.1177/0961203320959696 | View Paper |
| Publications : Cancer | Links |
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Functional Protein Microarrays for Parallel Characterisation of P53 Mutants Boutell, Jonathan M. et al. 2004. “Functional Protein Microarrays for Parallel Characterisation of P53 Mutants.” PROTEOMICS 4(7): 1950–58. http://doi.wiley.com/10.1002/pmic.200300722. | View Paper |
Seromic Analysis of Antibody Responses in Non-Small Cell Lung Cancer Patients and Healthy Donors Using Conformational Protein Arrays Gnjatic, Sacha et al. 2009. “Seromic Analysis of Antibody Responses in Non-Small Cell Lung Cancer Patients and Healthy Donors Using Conformational Protein Arrays.” Journal of Immunological Methods 341(1–2): 50–58. http://linkinghub.elsevier.com/retrieve/pii/S0022175908003244 | View Paper |
Protein Function Microarrays: Design, Use and Bioinformatic Analysis in Cancer Biomarker Discovery and Quantitation Duarte, Jessica, Jean-Michel Serufuri, Nicola Mulder, and Jonathan Blackburn. 2013. “Protein Function Microarrays: Design, Use and Bioinformatic Analysis in Cancer Biomarker Discovery and Quantitation.” In , 39–74. http://link.springer.com/10.1007/978-94-007-5811-7_3 | View Paper |
Serologic Autoantibodies as Diagnostic Cancer Biomarkers — A Review Zaenker, P., and M. R. Ziman. 2013. “Serologic Autoantibodies as Diagnostic Cancer Biomarkers–A Review.” Cancer Epidemiology Biomarkers & Prevention 22(12): 2161–81. http://cebp.aacrjournals.org/cgi/doi/10.1158/1055-9965.EPI-13-0621 | View Paper |
Development Of A Novel, Quantitative Protein Microarray Platform for the Multiplexed Serological Analysis of Autoantibodies to Cancer-Testis Antigens Beeton-Kempen, Natasha et al. 2014. “Development of a Novel, Quantitative Protein Microarray Platform for the Multiplexed Serological Analysis of Autoantibodies to Cancer-Testis Antigens.” International journal of cancer 135(8): 1842–51. http://www.ncbi.nlm.nih.gov/pubmed/24604332 | View Paper |
Novel Potential Serological Prostate Cancer Biomarkers Using CT100+ Cancer Antigen Microarray Platform in a Multi-Cultural South African Cohort Adeola, Henry A et al. 2016. “Novel Potential Serological Prostate Cancer Biomarkers Using CT100+ Cancer Antigen Microarray Platform in a Multi-Cultural South African Cohort.” Oncotarget 7(12): 13945–64. http://view.ncbi.nlm.nih.gov/pubmed/26885621 | View Paper |
Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin followed by Ipilimumab in Patients with Advanced Metastatic Melanoma Da Gama Duarte, Jessica et al. 2018. “Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin Followed by Ipilimumab in Patients with Advanced Metastatic Melanoma.” Frontiers in Immunology 9. http://journal.frontiersin.org/article/10.3389/fimmu.2018.00411/full | View Paper |
A Diagnostic Autoantibody Signature for Primary Cutaneous Melanoma Zaenker, Pauline et al. 2018. “A Diagnostic Autoantibody Signature for Primary Cutaneous Melanoma.” Oncotarget 9(55): 30539–51. http://www.ncbi.nlm.nih.gov/pubmed/30093967 | View Paper |
B cells and Antibody Production in Melanoma Da Gama Duarte, Jessica, Janique M. Peyper, and Jonathan M. Blackburn. 2018. “B Cells and Antibody Production in Melanoma.” Mammalian Genome. http://link.springer.com/10.1007/s00335-018-9778-z | View Paper |
| Publications : Neurodegenerative Diseases | Links |
|---|---|
Augmentation of Autoantibodies by Helicobacter pylori in Parkinson’s Disease Patients May Be Linked to Greater Severity Suwarnalata, Gunasekaran et al. 2016. “Augmentation of Autoantibodies by Helicobacter pylori in Parkinson’s Disease Patients May Be Linked to Greater Severity.” PloS one 11(4). http://view.ncbi.nlm.nih.gov/pubmed/27100827 | View Paper |
| Publications : Infectious Diseases | Links |
|---|---|
Autoantibody Profile of Patients Infected with Knowlesi Malaria Liew, Jonathan et al. 2015. “Autoantibody Profile of Patients Infected with Knowlesi Malaria.” Clinica chimica acta; international journal of clinical chemistry 448: 33–38. http://view.ncbi.nlm.nih.gov/pubmed/26086445 | View Paper |
Identifying Protein Biomarkers in Predicting Disease Severity of Dengue Virus Infection Using Immune-Related Protein Microarray Soe, Hui Jen et al. 2018. “Identifying Protein Biomarkers in Predicting Disease Severity of Dengue Virus Infection Using Immune-Related Protein Microarray.” Medicine 97(5): e9713. http://insights.ovid.com/crossref?an=00005792-201802020-00013 | View Paper |
COVID-19 Antibody Testing: From Hype to Immunological Reality Blackburn, Jonathan et al. 2020. “COVID-19 Antibody Testing: From Hype to Immunological Reality.” S Afr Med J. Published online 27 July 2020. https://doi.org/10.7196/SAMJ.2020.v110i9.15155 | View Paper |
Quantitative, Epitope-specific, Serological Screening of COVID-19 Patients Using a Novel Multiplexed Array-based Immunoassay Platform Blackburn, J., Anuar, N., Tan, T., Nel, A., Smith, M., Ellan, K., … Zain, R. (2020). Quantitative, Epitope-specific, Serological Screening of COVID-19 Patients Using a Novel Multiplexed Array-based Immunoassay Platform. MedRxiv, 40170, 2020.09.25.20201269. https://doi.org/10.1101/2020.09.25.20201269 | View Paper |
| Publications : Other Diseases | Links |
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A Novel Method to Identify Autoantibodies against Putative Target Proteins in Serum from beta-Thalassemia Major: A Pilot Study Sumera, Afshan et. al. 2020 “A Novel Method to Identify Autoantibodies against Putative Target Proteins in Serum from betaThalassemia Major: A Pilot Study.” Biomedicines 2020, 8(5), 97; https://doi.org/10.3390/biomedicines8050097 | View Paper |
Potential Novel Proteomic Biomarkers for Diagnosis of Vertebral Osteomyelitis Identified using an Immunomics Protein Array Technique Chen, Chang-Hua et al. 2020. “Potential Novel Proteomic Biomarkers for Diagnosis of Vertebral Osteomyelitis Identified using an Immunomics Protein Array Technique.” Medicine 99(43). https://journals.lww.com/md-journal/fulltext/2020/10230/potential_novel_proteomic_biomarkers_for_diagnosis.97.aspx | View Paper |
| Publications : Technology | Links |
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Protein Function Microarrays for Customised Systems-Oriented Proteome Analysis Blackburn, Jonathan M, and Aubrey Shoko. 2011. “Protein Function Microarrays for Customised Systems-Oriented Proteome Analysis.” Methods in molecular biology (Clifton, N.J.) 785: 305–30. http://www.ncbi.nlm.nih.gov/pubmed/21901609 | View Paper |
Advances in the Development of Human Protein Microarrays Duarte, Jessica G., and Jonathan M. Blackburn. 2017. “Advances in the Development of Human Protein Microarrays.” Expert Review of Proteomics 14(7): 627–41. https://www.tandfonline.com/doi/full/10.1080/14789450.2017.1347042. | View Paper |
Autoantibody-Based Diagnostic Biomarkers: Technological Approaches to Discovery and Validation Aziz, Farhanah et al. 2018. “Autoantibody-Based Diagnostic Biomarkers: Technological Approaches to Discovery and Validation.” IntechOpen DOI: 10.5772/intechopen.75200 https://www.intechopen.com/books/autoantibodies-and-cytokines/autoantibody-based-diagnostic-biomarkers-technological-approaches-to-discovery-and-validation | View Paper |
Applications of Functional Protein Arrays for Detection and Development of Autoantibody-based Diagnostics and Therapeutics Aziz, Farhanah et al. 2018. “Applications of Functional Protein Arrays for Detection and Development of Autoantibody-based Diagnostics | View Paper |
High-throughput autoantibody profiling against 1600+ proteins
Quantification of autoantibodies to 200+ clinically relevant CT antigens
Simultaneous screening of 100+
wild-type and mutant p53
Multi-antigen, multi-domain
COVID-19 antibody test
