Autoantibodies emerge early in the disease process, offering the potential to establish disease-specific signatures that support early detection—even before symptoms appear. These predictive signatures can identify disease states and guide timely intervention.

Autoantibody signatures also play a critical role in precision medicine, helping to match patients with the treatments most likely to benefit them. Companion diagnostics (CDx) based on these signatures ensure that only the right patients receive targeted therapies, enhancing treatment safety and effectiveness.

Our assays, which can analyze multiple autoantibody targets simultaneously, accelerate the discovery and validation of high-value predictive signatures—bringing us closer to earlier diagnosis and more personalized patient care.

Advancing Companion Diagnostics with Precision Autoantibody Profiling

Sengenics provides powerful solutions for identifying disease-specific biomarker signatures. Our protein microarrays offer precise, reproducible detection of disease-relevant autoantibodies directly from patient serum—even before symptoms appear. By targeting multiple autoantibody markers in a single assay, our platform accelerates CDx development to improve patient outcomes through precision medicine.

Related Study

Autoantibody Biomarkers for Predicting Anti-Drug Antibody (ADAb) Development in Adalimumab-Treated Rheumatoid Arthritis Patients

This heat map shows autoantibody presence and hierarchical clustering, illustrating patterns associated with anti-drug antibody formation and clinical response. Plasma samples were collected at baseline and after 24 weeks of adalimumab therapy. Autoantibody levels, measured in relative fluorescence units (RFU), are represented on a color scale for easy interpretation.

Source: Chen, P., et. al., Anti-TROVE2 Antibody Determined by Immune-Related Array May Serve as a Predictive Marker for Adalimumab Immunogenicity and Effectiveness in RA, Journal of Immunology Research (2021).

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