Overcoming a common challenge
Traditional array platforms use protein fragments, incorrectly folded or denatured proteins. Over 90% of antibody epitopes are conformational; they recognize the shape, not the amino acid sequence. Peptides and protein fragments are missing conformational epitopes and typically have exposed hydrophobic surfaces, resulting in non-specific antibody binding. This produces non-specific hits with a low signal-to-noise ratio.
Using our patented KREX® protein folding technology, Sengenics arrays feature full-length, correctly folded proteins. Conformational epitopes are preserved, resulting in highly specific hits with low background noise and reproducible results.