Improving p53 screening
The p53 tumor suppressor protein is a DNA binding protein. Wild type and mutated versions of p53 are important targets for immuno-oncology drug development.
Our OncoRex p53 Cancer Array provides a biologically relevant screening tool since all p53 variants are correctly folded and functional using our patented KREX® protein folding technology. Using our array, we can screen your therapeutic antibodies and protein binding compounds against more than 100 p53 wildtype and mutant variants by measuring their impact on DNA binding as a functional readout.