White Paper
Citrullination in Autoimmune Diseases
Explore the wide-reaching implications of citrullination – a protein post-translational modification in chronic inflammation – in our free comprehensive white paper.
Autoimmunity 2024
May 17 – 20, 2024 | Ljubljana, Slovenia | Booth 22
Sengenics is a proud sponsor of Autoimmunity 2024, the largest multidisciplinary international conference focused on autoimmune disorders and related diseases.
Meet us at Booth 22 or attend Dr. Frank Schmidt’s insightful talk on leveraging our advanced tools for precise autoantibody biomarker discovery in COVID-19. You can also meet with Dr. Schmidt in our booth for one hour following his talk on Saturday, from 1.00 to 2.00 PM.
Autoantibodies Are Ideal Biomarkers
Autoantibodies target the body’s own proteins and are generated by the humoral immune system, which constantly surveils the body for aberrantly-folded proteins often present in disease.
Below are six reasons why you should consider autoantibody biomarkers:
- Easy Collection: Non-invasive blood draws capture circulating autoantibodies.
- Enhanced Stability: Antibodies, less prone to degradation than mRNA and proteins, are easy to store and transport, facilitating longitudinal studies and remote sample collection
- Immune Insight: Autoantibodies are typically unaffected by common stimuli like exercise and diet, providing a direct glimpse into the immune response to disease
- High Specificity: Even low levels of autoantibodies are detectable for sensitive biomarker screening
- Early Detection: Autoantibodies are often expressed years before symptoms appear
- Diverse Applications: Autoantibodies can be used for diagnosis, prognosis, and patient stratification, as well as to understand disease mechanisms (Learn more)
Why Sengenics?
Since 90% of our antibodies target conformational epitopes, accurate autoantibody screening demands correctly-folded proteins that preserve these crucial binding sites – guaranteed by Sengenics KREX technology.
Discover why Sengenics excels in immunoproteomics:
- Full-length, correctly folded proteins
- Picomolar sensitivity
- Highly reproducible
- Low sample consumption
- Wide dynamic range
- High throughput
- Simultaneous analysis of two antibody isotypes (i.e., IgG and IgA or IgM)
- Off-the-shelf and custom options
- Distributors and service providers worldwide
With the i-Ome® Discovery array, screen against more than 1800 autoimmune, cancer, and neurological disease-related antigens in a single assay. Learn more
